| 0 | 0 | 4 |
| 下载次数 | 被引频次 | 阅读次数 |
为解决油墨分层、传感器的植入不适和数据准确性较低等问题，本研究优化了持续血糖监测(Continuous Glucose Monitoring,CGM)传感器的印刷工艺参数。首先，采用4因子3水平正交试验，探究静置时间、干燥能量、固化剂质量分数和印刷遍数对油墨分层的影响。然后，根据初始试验结果调整影响因子和水平，进行3因子3水平正交试验优化工艺参数，确定了静置时间和固化剂质量分数是影响油墨结合力的关键因素，得到了理论最优工艺参数为：静置时间5min、干燥能量280m J/cm2、固化剂质量分数3%，但考虑到实际生产中干燥不完全的风险，干燥能量推荐使用380m J/cm2。优化后的工艺参数组合有效解决了CGM传感器油墨分层问题，提高了其稳定性和可靠性，推动了血糖监测技术发展，为多层结构微传感器的印刷生产提供参考。
Abstract：To address issues such as ink delamination, sensor implantation discomfort, and low data accuracy, the printing process parameters for continuous glucose monitoring(CGM) sensors were optimized in this study. Firstly, a four-factor, three-level orthogonal experiment was conducted to investigate the effects of settling time, drying energy, mass fraction of the curing agent, and printing passes on ink delamination. Then, based on the initial experimental results, the influencing factors and levels were adjusted, and a three-factor three-level orthogonal experiment was conducted to optimize the process parameters. The results showed that settling time and curing agent content were the key factors affecting ink adhesion. The theoretically optimal process parameters were determined as follows: a settling time of 5 minutes, a drying energy of 280 mJ/cm2, and a mass fraction of the curing agent of 3%. However, considering the risk of incomplete drying in actual production, a drying energy of 380 mJ/cm2 was recommended. The optimized process parameter combination effectively solves the ink delamination problem of CGM sensors, improves the stability and reliability of CGM sensors, promotes the development of blood glucose monitoring technology, and provides a reference for the printing production of multi-layer structured microsensors.
[1]LIU Y,YU Q,LUO X,et al.Continuous Monitoring of Diabetes with an Integrated Microneedle Biosensing Device through 3D Printing[J].Microsystems&Nanoengineering,2021,7:75.
[2]American Diabetes Association Professional Practice Committee.Older Adults:Standards of Care in Diabetes—2024[J].Diabetes Care,2024,47(S1):S244-S257.
[3]BATTELINO T,ALEXANDER C M,AMIEL S A,et al.Continuous Glucose Monitoring and Metrics for Clinical Trials:An International Consensus Statement[J].The Lancet Diabetes&Endocrinology,2023,11(1):42-57.
[4]HU Y L,YANG D S,ZHANG H B,et al.A HighLinearity Glucose Sensor Based on Silver-Doped Con A Hydrogel and Laser Direct Writing[J].Polymers,2023,15(6):1423.
[5]WU M,LI L,YU R,et al.Tailored Diffusion Limiting Membrane for Microneedle Glucose Sensors with Wide Linear Range[J].Talanta,2024,273:125933.
[6]余江渊,李崭虹,陈诚,等.血糖监测用植入式传感器的研究进展[J].生物医学工程学杂志,2016,33(5):991-997.YU Jiang-yuan,LI Zhan-hong,CHEN Cheng,et al.Research Progress of Implantable Biosensors for Continuous Glucose Monitoring[J].Journal ofBiomedical Engineering,2016,33(5):991-997.
[7]高鑫禹,徐泽楷,陈力群.微创及无创血糖检测方法研究现状[J].生物医学工程学杂志,2023,40(2):365-372.GAO Xin-yu,XU Ze-kai,CHEN Li-qun.Research Progress on Minimally Invasive and Non-Invasive Blood Glucose Detection Methods[J].Journal of Biomedical Engineering,2023,40(2):365-372.
[8]LI X,ZHANG M,HU Y,et al.Developing a Versatile Electrochemical Platform with Optimized Electrode Configuration through Screen-Printing Technology Toward Glucose Detection[J].Biomedical Microdevices,2020,22(4):74.
[9]吕宣德,晏子强,陈寅杰,等.石英玻璃纤维织物基底柔性电极制备与性能研究[J].包装工程,2024,45(13):50-59.LV Xuan-de,YAN Zi-qiang,CHEN Yin-jie,et al.Preparation and Properties of Flexible Electrodes on Quartz Glass Fiber Fabric Substrates[J].Packaging Engineering,2024,45(13):50-59.
[10]GONG X,HUANG K,WU Y H,et al.Recent Progress on Screen-Printed Flexible Sensors for Human Health Monitoring[J].Sensors and Actuators A:Physical,2022,345:113821.
[11]梁华润,马浩轩,段新荣,等.柔性电化学传感器及其在无创医学检测中的应用[J].化学学报,2023,81(10):1402-1419.LIANG Hua-run,MA Hao-xuan,DUAN Xin-rong,et al.Flexible Electrochemical Sensors and Their Applications in Noninvasive Medical Detection[J].Acta Chimica Sinica,2023,81(10):1402-1419.
[12]付亚成,全昌云,刘丽霞,等.动态血糖监测系统中技术难点的相关探讨[J].中国医疗器械杂志,2022,46(4):422-427.FU Ya-cheng,QUAN Chang-yun,LIU Li-xia,et al.Technical Difficulties in the Implementation of the Continuous Glucose Monitoring System[J].Chinese Journal of Medical Instrumentation,2022,46(4):422-427.
[13]高志强,高艳飞,黄济超,等.基于丝网印刷的持续血糖监测试片的制备[J].数字印刷,2022,(4):174-179.GAO Zhi-qiang,GAO Yan-fei,HUANG Ji-chao,et al.Preparation of Continuous Blood Glucose Monitoring Test Strip Based on Screen Printing[J].Digital Printing,2022,(4):174-179.
[14]从晨浩.高精度全印刷碳基葡萄糖生物传感器的制备及性能研究[D].青岛:青岛大学,2023.CONG Chen-hao.Preparation and Performance Study of High Precision Fully Printed Carbon Based Glucose Biosensor[D].Qingdao:Qingdao University,2023.
[15]刘瑞江,张业旺,闻崇炜,等.正交试验设计和分析方法研究[J].实验技术与管理,2010,27(9):52-55.LIU Rui-jiang,ZHANG Ye-wang,WEN Chong-wei,et al.Study on the Design and Analysis Methods of Orthogonal Experiment[J].Experimental Technology and Management,2010,27(9):52-55.
[16]彭程,孟显品,邓坚.基于MPS方法的射流破裂正交实验及其模型研究[J].核动力工程,2024,45(4):181-189.PENG Cheng,MENG Xian-pin,DENG Jian.Study on Orthogonal Experiments of Jet Breakup and Its Modeling Based on MPS Method[J].Nuclear Power Engineering,2024,45(4):181-189.
基本信息:
DOI：10.19370/j.cnki.cn10-1886/ts.2026.02.012
中图分类号:TP212;TS805;TH789
引用信息:
[1]郑锋,孙惠芳,高艳飞,等.皮下植入式持续血糖监测微传感器印刷工艺参数优化研究[J].印刷与数字媒体技术研究,2026,No.241(02):116-123+165.DOI:10.19370/j.cnki.cn10-1886/ts.2026.02.012.
基金信息:
广东省普通高校重点领域专项（自然科学）（No.2022ZDZX4115）;广东省普通高校重点领域专项（自然科学）（No.2023ZDZX2091）; 广东省普通高校创新团队项目（自然科学）（No.2023KCXTD084）; 中山市第二批社会公益与基础研究项目（No.2023B2022）
2026-04-10
2026-04-10